【摘要】 目的 探讨妊娠合并哮喘及其病情控制程度与围产儿预后的关系。方法 对1990年1月至1999年12月间我院住院分娩的妊娠合并哮喘患者16例的临床资料进行回顾性分析。按病情控制程度分为发作组(9例)及缓解组(7例),并随机选取同期住院分娩的孕妇32例作为对照组,对3组新生儿出生体重、出生1分钟Apgar评分、羊水状况、早产及胎儿宫内发育迟缓(IUGR)等围产儿预后指标进行比较分析。结果 发作组新生儿出生体重低于缓解组及对照组(P<0.05),后两组差异无显著性(P>0.05);发作组剖宫产分娩、新生儿Ⅰ度窒息、IUGR及羊水异常的发生比例高于对照组(P<0.05);发作组早产的发生比例与后两组相比,差异无显著性(P>0.05);结论 妊娠合并哮喘时,病情反复控制不良者可导致多种围产儿并发症,需积极治疗减轻病情.改善围产儿预后。更多还原

【Abstract】 Objective To determine the influence of asthma and its severity during pregnancy on outcome of the infants. Methods 16 deliveries complicated by asthma between Jan. 1,1990 and Dec.31,1999 in our hospital were retrospectively studied,of which nine patients had medications during pregnancy,while the other seven patients need not. 32 normal deliveries were randomly selected as the control. The perinatal variables were compared amony the 3 groups. Results The birth weight in medication-dependent group was significantly lower than non-medication-dependent group and the control group ( P < 0.05) . The difference between the latter two groups was not significant (P > 0.05!) . Cesarean section rate and Apgar scores less than 7 at the first minute after birth were all significantly higher in the medication-dependent group,when compared with non-medication-dependent group and the controls ( P < 0.05) . No significant difference in preterm pregnancy was found ( P > 0.05); but when compared with controls,cases in medication-dependent asthmatic group was at significantly increased risk for intrauterine growth retardation and abnormal amniotic fluid ( P < 0.05). Conclusions Perinatal outcome of the infants is compromised in the pregnancy complicated by uncontroled or severe asthma. To achieve normal maternal function and a normal outcome of pregnancy. asthma should be treated aggressively in pregnant women as in non-pregnant women.更多还原