【摘要】 目的　探讨非小细胞肺癌中抗CD34 单抗标记的血管生成的表达状况。方法　采用免疫组化法检测 81例手术切除的非小细胞肺癌标本中抗内皮细胞表面抗原CD34 单抗标记的血管生成。结果　CD34 以其染色的特异性、敏感性及清晰的背景而易于识别。统计学分析显示微血管密度同肺癌临床分期的进展有密切关系 (P <0 .0 5 ) ,但与淋巴结转移及其它临床病理特征无明显关系 (P >0 .0 5 )。结论　肺癌中微血管密度在肺癌的发生、发展中可能起重要作用更多还原

【Abstract】 Objective To determine the expression of angiogenesis labelled by antiCD34 monoclonal antibody in nonsmall cell lung cancer. Methods Immunohistochemical detection for tumorassociated microvessels was performed to 81 nonsmall cell lung cancer tissues using antiCD34 monoclonal antibodies directed against endothelial markers. Results Staining of CD34 was easy to identify because of its specificity, sensitivity and clear background. Statistic analysis showed that the microvessel count was significantly related to the TNM staging but not to lymph node metastasis and other clinicopathologic characteristics. Conclusion MVD may play an important role in the oncogenesis and development of lung cancer.更多还原