【摘要】 目的　研究肺癌组织中微血管密度 (micro vasculardensity ,MVD)与肺癌病理生理特征及预后的关系。方法　采用免疫组化LSAB法 ,检测 114例肺癌组织、3 0例肺良性病变组织中的MVD。结果　①肺癌组织中MVD( 3 0 .3 7± 10 .5 6)显著高于肺良性病变组织 ( 10 .2 3± 6.2 9) (P <0 .0 1) ;②MVD与肺癌原发肿瘤大小 ,淋巴结转移状态 ,P TNM分期 ,细胞分化程度等均有密切关系 (P <0 .0 1) ,而与肺癌患者性别、年龄、吸烟史、肺癌原发部位、组织学类型等均无明显关系 (P >0 .0 5 ) ;③肺癌组织中MVD高密度(MVD≥ 3 0 )组患者 5年生存率 ( 17.2 7% )明显低于低密度 (MVD <3 0 )组 5年生存率 ( 5 2 .74% ) (P <0 .0 1) ;④MVD与肺癌患者术后生存期呈显著负相关 (r =-0 .5 2 1,P <0 .0 1) ;⑤多因素COX模型分析发现 :P TNM分期和MVD是判断肺癌预后最有价值的指标。结论　MVD在肺癌的发生、发展、转移中起重要作用 ,可作为肺癌生物学行为的一项评估指标 ,检测肺癌中MVD有助于预测肺癌预后及指导术后多学科综合治疗。更多还原

【Abstract】 Objective To study the relationship between MVD of lung cancer tissues and the pathophysiological characteristics and prognosis in patients with lung cancer. Methods The MVD was detected in 114 lung cancer tissues, 30 benign pulmonary tissues by immunohistochemical staining (LSAB method). Results MVD in lung cancer tissues (30.47±10.56) was significantly higher than that in benign pulmonary tissues (10.23±6.92)(P< 0.01 ); The MVD was closely related to the size of primary cancer, lymph node status, P TNM stages, grade of cell differentiation of lung cancer (P<0.01), but not to the histological classification and site of the cancer, and age, sex and smoking or not in the patients with lung cancer (P<0.05); The 5 year survival rate in patients (17.27%) with high MVD (≥30) was significantly lower than that in patients (52.74%) with low MVD (<30)(P<0.01); The survival time of patients with lung cancer was negatively related to MVD (r=-0.521,P<0.01); The results of multivariable COX model showed that the P TNM and MVD were the most significant variables for predicting prognosis among the all related factors in lung cancer. Conclusion Increase of MVD may play an important role in the oncogenesis, development, metastasis of lung cancer and might be served as a tumor marker to evaluate the biological behavior of lung cancer. Detection of MVD might be helpful to predict prognosis and guide the postoperative multi modality therapy in patients with lung cancer.更多还原