【摘要】 为探讨糖尿病大鼠低密度脂蛋白糖化率与动脉壁胶原含量变化的关系，将糖尿病大鼠并分为糖尿病组（ＤＭ），糖尿病氨基胍治疗组（ＡＧ）和对照组（Ｃ）。测定血糖（ＢＧ）、甘油三酯（ＴＧ）、胆固醇（ＴＣ）、低密度脂蛋白（ＬＣＬ）、糖化低密度脂蛋白（Ｇ－ＬＤＬ）及其糖化率（Ｋ）、糖化血红蛋白（ＨｂＡｌｃ）、动脉壁Ⅳ型胶原（ＣＩＶ）和Ⅲ型前胶原（ＰＣⅢ）。 ＤＭ组和ＡＧ组的ＢＧ水平高于Ｃ组（Ｐ＜ ０． ０１），但各组间的 ＴＧ、ＴＣ和ＬＤＬ水平无差异。ＤＭ组和 ＡＧ组的ＨｂＡｌＣ、和 Ｋ值显著高于 Ｃ组（ Ｐ＜ ０． ０１）。 ＤＭ组的动脉壁ＣＩＶ和ＰＣⅢ含量高于ＡＧ组和Ｃ组（ Ｐ＜０．０１）；Ｋ值与 ＣＩＶ和ＰＣⅢ含量呈正相关，（ｒ分别为０．８０６和０．８５１， Ｐ＜０．０１）。实验结果提示Ｇ－ＬＤＬ参与动脉壁的早期脂质沉积和胶原增加，是糖尿病动脉粥样硬化病变的重要促进因素之一。更多还原

【Abstract】 Objective:To investingate the relationship between LDL glycation rate and collagen content changes of arterial wall in diabetic rats. Methods: Diabetic rats were divided into 2 groups: diabetic rats (DM) and diabetic rats treated with amino - guanidine (AG) and a group of nor- mal rats served as control (c). Blood glucose (BG), triglyceride (TG), cholesterol (TC), low density lipoprotein (LDL), glycated LDL (G- LDL) and its glycation rate(K), glycated hemoglobin (HbAlc), arterial wall collagen Ⅳ (CIV) and precollagen Ⅲ (PCⅢ) were determined. Results: Bolld glucose in DM group and AG group was much higher than in C group (P <0.01), but there was no significant differences of TG, TC, and LDL levee in each group. HbAlc and K values were much higher in DM group and AG group than in C group (P <0.01). CIV and PC Ⅲ content was much higher in DM group than in AG group and group(P <0.01). There was positive correlation between K value and Contents of CIV and PCⅢ in arterial wall (r=0.806 and 0.851) respectively,(P <0.01). Conclution: G-LDL may contribute to the early lipid de-position and collagen in the arterial wall,and may be one of the important factors in promoting the atherogenic changes in diabetic rats.更多还原