【摘要】 目的:探讨内皮素(endothelin,ET)和肾上腺髓质素(adrenomedullin,AdM)在慢性支气管炎大鼠血浆、支气管肺泡灌洗液(bronchoalveolarlavagefluid,BALF)和肺组织中含量的变化及牛磺酸的影响。方法:实验分为慢支组、牛磺酸组和对照组,每组6只大鼠。大鼠吸入含10-6(体积分数)二氧化硫的混合空气建立慢性支气管炎模型。放免法测定ET1和AdM含量。结果:血浆、BALF和肺组织ET1含量,慢性支气管炎动物比对照动物分别增加239%、243%和367%(P<0.01),牛磺酸组比慢支组分别降低31.7%、36.7%和62.6%(P值分别小于0.05、0.01和0.01)。血浆、BALF和肺组织AdM含量,慢支组大鼠比正常对照大鼠分别增加40%、100%和138%(P<0.01),牛磺酸组大鼠比慢支组分别减少18.6%、28.5%和29.5%(P值分别小于0.05、0.01和0.01)。结论:慢性支气管炎病程中ET1和AdM可能发挥一定作用;牛磺酸可能通过阻止ET1和AdM调节紊乱的发生发挥保护作用。更多还原

【Abstract】 Objective: To examine the changes of endothelin 1(ET 1) and adrenomedullin(AdM) in chronic bronchitic rats and the effect of taurine. Methods: The rat model of chronic bronchitis was established by long term sulfer dioxide exposure. ET 1 and AdM levels in serum, bronchoalveolar lavage fluid(BALF) and lung tissue were measured by radioimmunoassay. Results: (1) In serum, BALF and lung tissue, ET 1 levels were increased by 239%, 243% and 367% respectively ( P < 0.01 ) in chronic bronchitic rats, while taurine decreased the ET 1 concentrations of chronic bronchitic rats by 31.7% ( P <0.05), 36.7% ( P <0.01) and 62.6% ( P <0.01) respectively. (2) In serum, BALF and lung tissue, AdM levels were increased by 40%, 100% and 138% respectively ( P <0.01) in chronic bronchitic rats, while taurine decreased the AdM concentrations of chronic bronchitic rats by 18.6% ( P <0.05), 28.5% ( P <0.01) and 29.5% respectively ( P <0.01). Conclusion: ET 1 and AdM may play a role in the pathogenesis of chronic bronchitis and taurine could show its protective effect by regulating the expression of the two peptides.更多还原