【摘要】 目的:观察美施康定( 硫酸吗啡控释片) 口服和直肠给药方式在重度癌痛治疗的止痛效果和副作用。方法:病例来源于1997 年6 月至1998 年7 月在本院住院和门诊就诊病人,共42 例晚期癌痛患者。开始时所有患者均口服美施康定,后因顽固性恶心呕吐或吞咽困难改为直肠给药,并与其口服时自身对照。结果:所有口服和直肠给药用美施康定的病人疼痛均得到持续性控制,剂量平均为前者55 .7mg q12h ,后者为53 .6mg q12h , P> 0 .05 ( t 检验) ,两者差异无显著性。口服和直肠给药的主要副作用是恶心呕吐和便秘,无精神依赖。直肠给药恶心呕吐的发生率(50 % ) 少于口服给药(74 % ) ,χ2 检验P< 0 .01 。所以,不能口服时直肠给予美施康定能很好的控制疼痛,是一种安全有效、简便的给药方式。更多还原

【Abstract】 Aim: To study the analgesic effect and side effects of MS CONTIN (Morphine Sulfate Modified Release Tablets) via different routes for severe cancer pain. Method: 42 patients in our hospital from June, 1997 to July, 1998 were recruited. At the beginning all the patients were given MS CONTIN p.o. Refractory nausea, deglutition difficulty or both occurred. So we shifted to rectal medication. Results obtained by the two methods were compared. Results: Oral medication lasted for an average of 82.5 days and rectal medication 22.5 days. The average dosage per day for oral use was 55.7mg, q12h, and rectal use 53.6mg, q12h (P>0.05). The occurrence rate of nausea for oral use was 74%, which was significantly higher than that for rectal use (50%, P<0.05). No psychic dependence was found in any cases. No local mucous irritation occurred. Conclusion: Rectal MS CONTIN is an effective method for the control of severe cancer pain, with less side effect of nausea.更多还原