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上皮性卵巢癌患者血清前白蛋白测定及其临床意义

The Clinical Significance of Analysis on Seru m Prealbu min in Wom en with Epithelial Ovarian Carcinom a

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【作者】 粟厚仪庄广伦

【Author】 Su Houyi Zhuang Guanglun( Department of Obstetric and Gynecology , First Affiliated Hospital , Sun Yat sen University of Medical Sciences, Guangzhou ,510080)

【机构】 中山医科大学附属第一医院妇产科!广州510080

【摘要】 目的:了解血清前白蛋白( Prealbumin ,简称 P A) 水平与上皮性卵巢瘤生物学行为的关系及其临床意义。方法:采用琼脂糖免疫单向扩散法测定58 例上皮性卵巢癌、35 例上皮性卵巢瘤和30 例正常人血清前白蛋白。同时用放免法测定上述检测对象血清癌抗原125(cancer antigen 125 ,简称 C A125) 。结果:上皮性卵巢癌组血清 P A 低于上皮性卵巢瘤组及正常人组( P= 0003) 。且肿瘤临床分期越晚、分化越差, P A 水平越低( P < 0001 ; P = 0027) ;术后肿瘤残存与血清 P A 低水平有关( P =0014) 。 P A 与 C A125 呈负相关, Spearman′s 系数为- 068( P < 001) , P A 越低 C A125 越高,与上皮性卵巢癌恶性生物学行为一致。结论: P A 与上皮性卵巢癌恶性行为密切相关,可作为上皮性卵巢癌病情及预后估计较敏感的参考指标。

【Abstract】 Objective : To clarify the impact of epithelial ovarian carcinoma and the level of serum prealbumin ,apotential new tumor markerfor epithelial ovarian carcinoma . Methods : Serum prealbumin was detected in 58 women withepithelial ovarian carcinoma ,35 women with benign epithelial ovarian tumor and 30 normal women by ager single diffu sion technique , while the serum C A125 (cancer antigen125) was determined by radioim munoassay . Results : Low serumprealbumin associated with malignant property in epithelial ovarian carcinoma . Lower serum prealbumin was ,later theclinical stage was and poorer tthe differentiation was ( P < 0 05) . The level of serum pealbumin was negatively relatedwith the level of C A125 (cancer antigen 125) . Spearmen′s coefficient was - 0 .68 ( P < 0 01) . Conclusions : Serumprealbumin may be a useful new markerforthe prediction and prognosis valuation of epithelial ovarian carcinoma .

【基金】 中山医科大学科研基金
  • 【文献出处】 中山医科大学学报 ,ACADEMIC JOURNAL OF SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES , 编辑部邮箱 ,1999年03期
  • 【分类号】R737.31
  • 【下载频次】33
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