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复方马钱子片质量标准的研究
Effect of Recipes of TCM with Strengthening Spleen or Tonifying Kidney on Cellular Immunity in Rats
【摘要】 按新药审评标准对复方马钱子片进行了质量标准的研究,建立了4味主药的鉴别方法,并用正相高效液相色谱法对主要活性成分士的宁进行了含量测定。结果显示:本方法准确、可靠,分离度和重现性好,能作为本片剂的质控标准。
【Abstract】 In this paper,3 recipes of TCM,strengthening spleen(ss),tonifying kidney(tk)and combination of the two grous(sstk) were studied with immunodificiency rats induced by cyclophosphamide.The results showes that the weights of spleen and thymus were reduced in the model group,after treating the weights of spleen and thymus in these 3 groups were all increased,the level of CD 3,CD 4,CD 8 and CD 25 were decreased while CD 4/CD 8 ratio were increased significantly than those of in the blank control group.Levels of CD 3 and CD 25 in the ss group were higher than in the control group,Levels of CD 3,CD 4,CD 8 and CD 25 in tk and sstk groups were increased remarkably,but the CD 4/CD 8 ratio were lowered in both of the two groups.It is found that every parameters in the two groups were improved and are better than those in the ss group.
【Key words】 strengthening spleen; tonifying kidndy; cyclophosphamid; T lymphocyte subsets;
- 【文献出处】 中国实验方剂学杂志 ,CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE , 编辑部邮箱 ,1999年03期
- 【分类号】R286.0
- 【被引频次】1
- 【下载频次】136