【摘要】 通过对２型糖尿病（ＮＩＤＤＭ）核心家系的分析，探讨了遗传因素在核心家系成员中所起作用的程度。结果表明：病例核心家系一级亲属ＮＩＤＤＭ 的发病率非常显著的高于对照组，χ２ ＝ １７．０，Ｐ＜ ０．００１，相对危险度（ＲＲ）为３．３０，９５％ 可信区间为１．８０～６．０５。不论父母、同胞和子女，均以病例亲属的发病率显著高于对照；病例组各亲属中，不论男女和年龄，标准化发病率比（ＳＩＲ）均明显高于对照人群的１００，经统计学Ｚ检验有极显著意义；病例核心家系的ＲＲ、归因危险度（ＡＲ）％ 也明显较高，进一步说明血缘关系与ＮＩＤＤＭ 之间有较强的联系。更多还原

【Abstract】 A genetic epidemiological case control study was carried out to estimate the genetic susceptibility in nuclear family member of NIDDM in Changzhou city in March 1998.The results showed that the incidence rate of NIDDM in first degree relatives was significantly higher than that in controls,χ 2=17 0, P <0 001.The relative risk (RR) of nuclear family member in cases was 3 3(95% CI,1 80~6 05).All standardized incidence rates (SIR) of the blood relatives in the case nuclear family were significantly higher than 100 which was in the controls.RR and the attributable risk (AR)% in the case nuclear family were also higher.It means that there was a strong relationship between blood relatives and NIDDM.更多还原