【摘要】 目的研究P53、Bcl-2、P16和c－myc基因在卵巢上皮性肿瘤中的意义。方法采用免疫组织化学法（SABC法）对80例良性、26例交界性和116例恶性卵巢上皮性肿瘤P53、Bcl-2、P16和c-myc癌基因的表达情况进行检测。结果P53、Bcl-2、P16和c－myc表达率分别为36．48％、27．47％、83．33％和52．25％，P53、Bcl-2、c-myc表达随恶性程度增加而增高，良恶性之间表达差异有显著意义（P＜0．01），P16随恶性程度增高表达率降低，恶性和良队间表达差异有显著性（P＜0．01），恶性肿瘤中的P53\、Bcl-2和c－myc随分期增加，表达增加。结论四种癌基因在卵巢上皮性肿瘤中高表达或表达失调，良恶性之间表达差异有显著意义，表明它们在卵巢上皮性肿瘤发生、发展中起重要作用。更多还原

【Abstract】 To investigate expression of P53 Bcl-2. P16 and c-myc genes in ovallan epithelialtumors and relationship between expression and genesis and prognosis and its role. Methods ApplicationImmunohistochemistic methods, studied expression of P53. Bcl-2. P16 and c-myc genes in ovarian epithelialtumors included 80 cases benign, 26 borderline and 116 malignant tumors. Results expression on rates of P53Bcl-2. P16 and c-myc were36. 48 %, 27. 4%, 83. 33 % and 52. 25 % respectively. The expression of c-myc was increased with malignancy high, It has significant different between benign and malignant (P＜0.01). The expouion rate of P16 was decreased with malignancy high and it has significance concern with tumor behavior (P＜0.01). The expression of P53. Bcl-2 and c-myc in ovarian malignant tumor were related to the stage.更多还原