【摘要】 目的探讨内皮素１（ＥＴ１）在妊高征发病中的作用。方法采用放射免疫法检测７０例妊高征患者（妊高征组）和３０例正常妊娠妇女（正常妊娠组）血浆ＥＴ１水平，用免疫组化及原位杂交方法检测ＥＴ１及ＥＴ１ｍＲＮＡ在妊高征及正常妊娠胎盘绒毛组织的表达。结果（１）妊高征组血浆ＥＴ１水平（７５０８±１６．３５）ｎｇ／Ｌ，明显高于正常妊娠组（４７６２±８６６）ｎｇ／Ｌ，病情越重其值越高，且ＥＴ１水平与妊高征患者平均动脉压呈正相关关系。（２）胎盘绒毛组织合体滋养细胞及胎儿血管内皮细胞有ＥＴ１及ＥＴ１ｍＲＮＡ的表达，且妊高征组胎盘绒毛组织ＥＴ１及ＥＴ１ｍＲＮＡ阳性信号较正常妊娠组增强。结论血管内皮损伤与妊高征的发病有关，胎盘绒毛组织ＥＴ１增高在妊高征的发病中起重要作用。更多还原

【Abstract】 Objective To investigate the role of endothelin (ET 1) in the pathogenesis of pregnancy induced hypertension (PIH). Methods In 70 cases of PIH the plasma concentration of ET 1 was measured by RIA, and the expressions of ET 1 and its mRNA in placental villus were determined by immunohistochemistry and in situ hybridization respectively. 30 normal pregnant women (NP) served as control group. Results (1) The Plasma concentration of ET 1 was significantly higher in PIH than that in NP. There was a positive correlation between the plasma ET 1 level and mean arterial pressure in PIH. (2) The expressions of ET 1 and ET 1 mRNA were found in syncytiotrophoblast of placental villus and in the endothelium of fetal vessels. These positive signals were higher in PIH than in NP. Conclusion The injury of endothelium of fetal and placental blood vessels was one of the causes of PIH. The placenta may play an important role in the pathogenesis of PIH.更多还原