【摘要】 对中国核工业职业人群原发性肝癌死亡调查及有关资料进行分析,探讨肝癌发生可能存在的危险因素,为制定防治措施提供参考依据。调查对象为11个单位组建至1990年底在册职工,分组、分行业、分性别观察分析,调查历年职工人数及死亡病例,按ICD-9原则统计,并结合有关体检实验室检查结果及某些临床流行病学资料进行总结。调查结果显示肝癌累计粗死亡率为19.20×10^-5,标化死亡率为10.09×10^-5;死亡多集中于35～54岁年龄组。SMR等于1.00（P>0.05）,扩散元件系统SMR等于1.43（P<0.05）,其余未见增加;RR值在铀矿系统为3.67（P<0.01）,其余无增加意义。肝大检出率、GPT增高检出率均小于10％或居10％左右,HBsAg检出率均小于8％,居全国中等感染水平。肝癌病例的HBsAg检出率为61.6％,而合并慢性肝炎者为53.4％。结论为核工业职工总体肝癌死亡未见增加,仅见铀矿系统表现为有意义增加,目前无证据归因于放射性作业影响。核工业职工肝癌死亡主要危险因素可能为HBV感染,其次为慢性肝炎或环境因素。更多还原

【Abstract】 To evaluate primary liver cancer death in the workers of China nulcear industry and to discuss the risk factors probably for making protection and cure measures, the workers of 11 units are surveyed from the time of foundation to the end of 1990 by groups, trades and sex, and the results are analyzed with the relevant physical examinations, the results in laboratory test, and some clinic epidemilogical data concerned. The accumulative rough mortality is 19.20X 10-5, standard mortality 10.09X10-5, the most is at the age of 35 to 54. SMR 1.00(P>0.05), RR value in uranium mines is 3.67 (P<0.01) and others does not increase. The incidence of hepatomegalia and GPT rising are lower than or about 10%, while the incidence of HBsAg is lower than 8%, a middle-levelled infection in the country. And HBsAg incidence in liver cancer cases is 61.6% and chronic hepatitis in liver cancer cases is 53.4%. The liver cancer case increase in the workers in nuclear industry is not found, but significant increase is found in uranium mine workers; whereas there is no evidence that can be attributed to radiation operation, and the death risk may be considered mainly to be related to HBV infection, then chronic hepatitis or environment factors.更多还原