【摘要】 目的：研究不同浓度补骨脂中补骨脂素和异补骨脂素的鼻粘膜吸收规律。方法：建立大鼠鼻腔重循环模型，用ＨＰＬＣ 法测定循环液中补骨脂素和异补骨脂素的含量变化。结果：补骨脂中补骨脂素和异补骨脂素在鼻粘膜的吸收符合零级动力学特征，随着药液浓度的增加，补骨脂素和异补骨脂素的吸收存在饱和现象。结论：在开发补骨脂鼻腔给药制剂时，要控制恰当的浓度。更多还原

【Abstract】 Objective:To investigate the nasal absorption regularities of psoralen and isopsoralen of different concentrations.Method:Building an experimental model of rat in situ nasal recirculation and determining the contents of psoralen and isopsoralen by HPLC.Result:The nasal absorption of psoralen and isopsoralen fitted in with zero order kinetics,getting saturated with the increase of concentration.Conclusion:A suitable concentration is necessary for the preparation of nasal remedies psoralen and isopsoralen.更多还原