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铁路危险品货运站空气污染颗粒提取物的SOS/umu试验
Application of SOS/umu Assay Study on Genotoxicity of Dangerous Chemical Articles Transportation Railway Station(DCATRS)
【摘要】 铁路危险品货运站 (以下简称危货站 )是各种易燃易爆及有毒害化学品的集散地 ,空气污染严重。为探讨危货站空气污染物对DNA可能产生的损伤效应 ,采用SOS/umu试验对危货站空气污染物的遗传毒性进行了分析。结果表明 :在未加S9活化系统的条件下 ,显示出遗传毒性并有明显地剂量—反应关系 ;加入S9活化系统后 ,未见遗传毒性。提示我们危货站空气污染物具有直接遗传毒性作用。
【Abstract】 Air pollution is serious in Dangerous Chemical Articles Railway Transportation Station(DCARTS)as collection、storage and transportation sites of dangerous chemical articles.The genotoxicity of air pollution in DCARTS is studies by SOS/umn Assay.The results showed that air pollution of DCARTS in test induced significant SOS response to TA1535/PSK1002 strain and obvious dose-response relationship.It had not shown geontoxicity with liver microsomal metabolic activation.It indicated that air pollution of DCARTS had direct mutagenesis.
【Key words】 SOS/umu testdangerous chemical articlesair pollutiongenotoxicity;
- 【文献出处】 预防医学情报杂志 ,JOURNAL OF PREVENTIVE MEDICINE INFORMATION , 编辑部邮箱 ,1999年03期
- 【分类号】R126.4
- 【被引频次】2
- 【下载频次】43