【摘要】 目的：探讨脂糖舒对小鼠脑缺血的影响。方法：急性脑缺血模型采用断头术和双侧颈总动脉结扎两种方法复制。小鼠随机分为三组，分别给予脂糖舒（20g／kg）、生理盐水和尼莫地平（15mg／kg）。给药后将各组的半数小鼠行断头术并测定其喘息时间，另半数小鼠行双侧颈总动脉结扎并记录其存活时间。结果：断头小鼠脂糖舒组的喘息时间比生理盐水组明显延长（32．08±4．28秒　vs．25．80±6．26秒，p＜0．01），但短于尼莫地平组（33．92±3．88秒）。颈总动脉结扎小鼠脂糖舒组的存活时间也比生理盐水组明显延长（57．48±28．16分vs．16．37±8．02分，P＜0．01），但亦短于尼莫地平组（58．01±17．9分）。结论：较大剂量脂糖舒对脑缺血机体有一定的保护作用。更多还原

【Abstract】 To observe the influence of Zhi- Tang - Shu (ZTS) on micesuffering encephalic ischemia. Method The model of acute encephalic ischemia were established bydecapitation or bilateral carotide ligation. Firstly, the mice were randomly divided into three groupsWhich administrated with ZTS (20g/kg ), normalsaline and Nimodiping (15mg/kg) respectively.After administration, the half mice of all groups were decapited and their asthmatic times weredectected,the another half were made bilateral ligation and their survival times were recorded.Results In decapitated mice, the asthmatic time of ZTS group was obviously longer than that ofnormalsaline group(32. 08 ±4. 28sec vs 25. 80 ±6. 26see, P < 0. 01 ), but briefer than that ofNimodiping group(33. 92 ±3. 88sec). In carotid ligate mice, the survival time of ZTS group wastoo obviously longer than that of normalsaline group(57. 48 ± 28. 16min vs 16. 37 ± 8. 02min, P<0. 01 ), and also briefer than that of Ninediping group (58. 01 ± 17. 90min). Conclusion Arelatively large dosage of ZTS can protect organism from encephalis ischemia.更多还原