【摘要】 目的：探讨转化生长因子β1和冠心病（CAD）的关系。方法：采用ELISA法检测303例CAD患者和68例健康对照者血浆中活化的转化生长因子β1（TGFβ1）和总TGFβ1的含量。结果：CAD患者总TGFβ1水平与对照组的水平无明显差异（P＞0．20），但活化的TGFβ1水平CAD患者明显高于对照组（P＜0．001）。随着病变冠脉数量增加，活化TGFβ1水平亦呈线性增加（P＜0．001），三支冠脉病变患者的活化TGFβ1水平是对照组的两倍。结论：血浆活化TGFβ水平增高可能与CAD发生发展有密切关系。更多还原

【Abstract】 Objective: To explore the association of transforming growth factor β1(TGFβ1) with coronary artery disease (CAD). Methods: The plasma active and total TGFβ, levels were measured in 303 pahents with CAD and 68 normal persons by the method of ELISA. Results: The plasma total TGFβ1 level was not signicantly different among patients with or without angiographically demonstrable CAD(P>0. 20); Level of active TCFβ1was significanhy higher in CAD patients than that in coneal group (P < 0.001 ) and it was increased linearly with CAD severity (P < 0.001). The active TGFβ1, level in patients with three ill vessels was twice as high as the level of those without ill vessels. Conclusion: These results suggest that the increase of active TGFβ1 level may be closely related to the occurrence and seventy of CAD.更多还原