【摘要】 目的　研究白细胞介素６（ＩＬ６）和肿瘤坏死因子（ＴＮＦα）在翼状胬肉发病机理中的作用。方法　采用细胞生物活性法和放射免疫检测技术检测了３０例患者翼状胬肉组织的体外培养上清中和正常组织中ＩＬ６和ＴＮＦα的含量。结果　翼状胬肉组织培养上清中的ＩＬ６ 和ＴＮＦα含量分别为１９．８±１２．１ｋＵ·ｇ－ １ 蛋白和４３．８±２２．１μｇ·ｇ－ １，均明显高于正常球结膜组（４．７±１．６ｋＵ·ｇ－ １蛋白和９．４±３．６μｇ·ｇ－ １ 蛋白，Ｐ＜ ０．０１）；进行期组的ＩＬ６ 和ＴＮＦα含量分别为２１．４±１１．９ｋＵ·ｇ－ １ 蛋白和５６．６±２３．８μｇ·ｇ－ １蛋白，均明显高于静止期组（１６．９±１２．３ｋＵ·ｇ－ １蛋白和２９．２±１４．３μｇ·ｇ－ １蛋白，Ｐ＜ ０．０５），且抗ＴＮＦα抗体对ＩＬ６ 的产生具有负向的调节作用。结论　翼状胬肉的发生、发展可能与ＩＬ６ 和ＴＮＦα的异常分泌有关更多还原

【Abstract】 Objective To study the roles of interleukin 6(IL 6)and tumor necrosis factor(TNF α)in the pathogenesis of pterygium.Methods Bioactivity assay and radioimmunoassay were used to measure the levels of IL 6 and TNF α in tissue cultural supernatant of pterygium specimens in 30 patients.Results The levels of IL 6 and TNF α in tissue cultural supernatant of pterygium were significantly higher than that of normal conjunctival specimens (P<0.01),and there was a significant difference between cases and the quiescent cases (P<0.05).Conclusion The abnormal secretion of IL 6 and TNF α may be a positive factor in the pathogenesis of pterygium.更多还原