【摘要】 本研究探讨十一酸睾酮抗雄性大鼠生育的机制。１２周龄雄性ＳＤ大鼠，给药组８只每２周注射２０ｍｇ／ｋｇ十一酸睾酮，共３个月。与１０只对照大鼠比较，十一酸睾酮处理大鼠睾丸网液中精子密度下降到对照组的７％，附睾尾部精子活动力下降至对照组的６％，血清睾酮水平上升至对照组的２５５％，而睾丸网液睾酮却下降至对照组的５５％。两组之间均有非常显著差异。未发现十一酸睾酮处理大鼠睾丸生殖细胞和附睾上皮细胞凋亡状况有明显改变，但睾丸和附睾的雄激素受体基因表达显著低于对照组大鼠。十一酸睾酮抑制睾丸精子生成和降低附睾精子活动力可能与睾丸网液的雄激素水平下降以及睾丸和附睾雄激素受体基因表达的抑制有关。更多还原

【Abstract】 The mechanism of antifertility effect of testosterone undecanoate (TU) on male rat was investigated. Eight 12 week rats were injected with 20 mg/kg of testosterone undecanoate at bi weekly intervals for 3 months. As compared with 10 control rats, the sperm density in testis rete fluid of the treated rats declined to 7% and the motility of sperm from epididymus cauda reduced to 6%. While the testosterone level in serum increased to 255%, the testosterone level in the rete fluid decreased to 50%. All of these differences were significant. No significant difference was found in the apoptosis of germ cells between the treated and control groups, but the androgen receptor gene expression in the testis and epididymus was suppressed in the treated group. The decrease in output of the sperm and sperm motility of epididymus cauda may be due to the reduced testosterone production by Leydig cells and suppression of androgen receptor in testis and epididymus.更多还原