【摘要】 目的探讨肝硬化患者血清透明质酸含量与肝硬化病变程度及甲状腺激素水平的相关性。方法用放射免疫法测定了６９例不同程度的肝硬化患者血清透明质酸（ＨＡ）含量和甲状腺激素水平。结果随着临床肝硬化程度的加重，ＨＡ含量逐渐增高。而三碘甲状腺原氨酸（Ｔ３）、游离三碘甲状腺原氨酸（ＦＴ３），随ＨＡ的增高而下降，与ＨＡ含量呈显著负相关（ｒ＝－０．６２１和－０．４８４）；而甲状腺素（Ｔ４）、游离甲状腺素（ＦＴ４）可正常或下降，但在肝功能严重衰弱时也多呈低水平。结论肝硬化时，Ｔ３、ＦＴ３与ＨＡ呈显著负相关。联合检测ＨＡ与Ｔ３、ＦＴ３及Ｔ４、ＦＴ４浓度对估测肝硬化的严重程度及预后具有实用价值。更多还原

【Abstract】 Objective\ The relevont study of hagluronic acid and thyrosin in pations with different degree live cirrhosis.The concentration of serum hyaluronic acid and thyroxine were determined by radioimmunoassy in 69 patients with different degrees of liver cirrhosis.Result\ It is showed that the serum HA increased gradually with the degree of clinical liver cirrhosis deteriorated.But T 3、FT 3 decreased along with the increased HA.There was a significantly negative relation between T 3、FT 3 and HA (r=-0.621,r=-0.484).However,T 4、FT 4 may be normal or lower,But they wer most likely in a low concentration when liver function deteriorated seriously.Conclusion\ It is suggested that there is a significantly negative relation between T 3、FT 3 and HA.Measuring the concentration of HA、T 3、FT 3、T 4 and FT 4 simultaneously has utilizable and reliable clinical value in predicting the degrees and prognosis of liver cirrhosis.更多还原