【摘要】 应用 Ｎ Ａ Ｄ Ｐ Ｈｄ 组织化学方法研究了大鼠第三脑室视前区室管膜的伸展细胞⒚结果表明：１）第三脑室视前区室管膜存在 Ｎ Ａ Ｄ Ｐ Ｈｄ 阳性的伸展细胞，其基突伸向视前区并与神经元或毛细血管相接触；２） Ｎ Ａ Ｄ Ｐ Ｈｄ 阳性的伸展细胞在第三脑室侧壁常见、室底少见、室顶未发现其存在；３） Ｎ Ａ Ｄ Ｐ Ｈｄ 阳性的伸展细胞的形态与分布，在雌、雄大鼠间不存在明显的性别差异⒚尽管 Ｎ Ａ Ｄ Ｐ Ｈｄ 阳性的伸展细胞的生理功能不十分清楚，但本研究为伸展细胞作为脑脑脊液环路的一部分，介导下丘脑对脑脊液中化学变化的感受提供了形态学依据，并提示一氧化氮可能参与了这一过程⒚更多还原

【Abstract】 In the present study, the ependymal tanycytes of the third ventricle in preoptic region (POR) of rat were investigated using NADPH diaphorase(NADPH d)histochemistry. It was found: 1) there existed the NADPH d positive tanycytes with their basal processes projecting to POR and contacting with neurons or capillaries; 2) the NADPH d positive tanycytes were frequently observed in the lateral walls of the third ventricle , but less commonly at the floor, and not found at the roof; 3) there was no significant sex differ ence in morphology and distribution of the NADPH d positive tanycytes. Although the physiological role of the NADPH d positive tanycytes is still poorly understood, the present investigation provides morphological evidence supporting that tanycyte may be a part of the brain cerebrospinal fluid circuit, serving important function of sensing chemical changes of cerebrospinal fluid (CSF), and that nitric oxide (NO) may contribute to this process.更多还原