【摘要】 目的:评价尿激酶不同给药途径的溶栓效果及安全性。方法:将新鲜兔血栓注入新西兰白兔的一侧颈内动脉（1CA）,15min后经不同的途径给予尿激酶（UK）治疗。结果:治疗开始后2h内动脉途径组(10000u·kg^-1)血管再通率100%;静脉途径组(10000和20000u·kg^-1)分别为33%和100%。动脉途径组平均再通时间（53.6±13.1）min,静脉途径组(20000u·kg^-1)为（89.1±14.8）min。结论:动脉途径的溶栓效果及安全性优于静脉途径。更多还原

【Abstract】 Aim: To evaluate the thrombolytic efficacy and safety of different urokinase (UK)therapy routes by doppler ultrasonics. Methods: A fresh blood clot was injected into one internal carotid artery of a New Zealand white rabbit. 15 min later, UK was administrated by different routes, and ICA blood flow was detected by doppler ultrasonics. Results: ICA blood flow was reestablished within 2 h in all rabbits treated with a regional intra-arterial UK infusion, 2 out of 6(10 000u·kg-1)and 10 out of 10(20 000u·kg-1)in the groups treated with intravenous infusion, respectively. The mean reestablishing time of the flow was(53. 6±13.1)min and (89. 1± 14.8)min in the groups treated with a regional intra-arterial UK infusion and in the group treated with intravenous infusion (20 000u·kg-1), respectively. Conclusion: The thrombolytic efficacy and safety of UK administrated in regional intra-arterial UK infusion were superior to that administrated in intravenous infusion.更多还原