【摘要】 为探讨夜间睡眠3小时血生长激素平均浓度(3h-ICGH)在矮小身材患儿中的意义,对35例青春期前的矮小患儿进行生长激素刺激试验(GHST)及3h-ICGH测定。结果显示:生长激素缺乏(GHD)组MP-GH(3.05±2.34μg/L)及3h-ICGH(1.27±0.56μg/L)均极显著低于正常矮小(NSS)组(分别为14.47±4.85μg/L,9.64±6.33μg/L,P均<0.001);生长激素神经分泌功能紊乱(GHND)组3h-ICGH(2.71±0.93μg/L)显著低于NSS组(P<0.05)。与GHND组相比,GHD组MP-GH明显低下(P<0.001),3h-ICGH也显著低于GHND组(P<0.01)。提示3h-ICGH对临床上GHND的筛查有一定的参考价值。更多还原

【Abstract】 To clarify the clinical significance of blood 3h-integrated concentration of growth hormone(3h-ICGH) determination during sleeping in night for the classified diagnosis of children with short stature. GH stimulating test and blood 3h -ICGH were prospectively carried out in 35 pre -adolescent children with short stature. From the data, it was discovered that both mean peak of GH(MP-GH, 3. 05±2. 34μg/L and blood 3h - ICGH.1. 27±0. 56μg/L) in GH deficiency (GHD) group ’were very significantly lower than those in normal short stature (NSS) group(14. 47±4. 85μg/L and 9. 64±6. 33μg/L separately, both P<0. 001) . On the other hand, 3h -ICGH value (2. 71±0. 93μg/L) in the group of GH neurological dysfunction (GHND) was also found to be significantly lower than that in NSS group (P<0. 05). More meaningfully, when compared with those in GHND group, these two determinations in GHD group were found to be significantly lower(P<0. 001 and P< 0. 01). All these results seem to indicate that blood 3h -ICGH determination might have a reference value in screening out of GHND from children with short stature in clinical work.更多还原