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进口与国产尼莫地平注射液与常用输液液体配伍稳定性比较

Comparison of stability between import and domestic nimodipines

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【作者】 陈晓岚; 贾陆; 卢建莎; 阿有梅; 潘成学; 张红岭;

【Author】 Chen Xiaolan 1) ,Jia Lu 2) ,Lu Jiansha 1) , A Youmei 2) , Pan Chengxue 2) ,Zhang Hongling 2) 1)Organic Teaching and Research Division, Henan Medical University, Zhengzhou 450052 2)Pharmaceutical Department, Henan Medical Unive

【机构】 河南医科大学有机化学教研室!郑州4500522; 河南医科大学药学系!郑州450052;

【摘要】 目的:考察进口和国产尼莫地平注射剂与常用的输液液体配伍的稳定性。方法:利用分光光度法,测定进口和国产尼莫地平注射剂在50 g/L葡萄糖和f9 g/L氯化钠注射液液体中,于18 ℃和37 ℃避光和不避光条件下,不同时间段内吸光度变化。结果:不同条件下国产与进口尼莫地平注射剂与常用输液配伍后的吸光度变化程度基本一致,认为在NaCl 溶液中6 h 内是稳定的,而在葡萄糖溶液中2 h 内稳定。结论:国产与进口尼莫地平与输液配伍后不同时刻点平均值之间差异无显著性

【Abstract】 Aim: To compare the stability of import and domestic nimodipines by dissolving in 50 g/L glucose injecta and 9 g/L sodium chloride injecta under different conditions respectively. Methods: Determining the absorbance of infusion under different conditions by UV. Results: The absorbance of import and domestic infusions under the same conditions showed no obvious differences. They are stable in the sodium chloride injecta within 6 h and in the glucose injecta within 2 h. Conclusion: The average absorbance of import and domestic nimodipines shows no obvious change during different time. They owned similar stability.

【关键词】 尼莫地平; 配伍; 稳定性; 葡萄糖; 氯化钠;
【Key words】 nimodipine; match; stability; glucose injecta; sodium choride injecta;
  • 【文献出处】 河南医科大学学报 ,JOURNA OF HENAN MEDICAL UNIVERSITY , 编辑部邮箱 ,1999年04期
  • 【分类号】R942
  • 【被引频次】3
  • 【下载频次】130
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