【摘要】 目的：研究组合硬化剂对家兔胆囊的硬化作用，观察治疗肾囊肿的远期临床疗效。方法：应用四环素与氟美松组合硬化剂注入家兔胆囊，与生理盐水和无水乙醇对比观察其对胆囊壁的作用；与无水乙醇对比观察介入硬化治疗肾囊肿的疗效。组合硬化剂治疗组４１ 例，男２３ 例，女１８ 例，年龄４３ 岁～７２ 岁；无水乙醇对照组４０ 例，男２８ 例，女１２ 例，年龄４５ 岁～７０ 岁。结果：动物实验，生理盐水组胆囊上皮均无组织学异常改变；无水乙醇组胆囊内出血渗液多，吸收慢，纤维组织增生少；组合硬化剂组胆囊内渗液少，吸收快，纤维组织增生明显。临床治疗肾囊肿，组合硬化剂具有刺激囊内渗液量少，囊腔闭合快，治愈率高，无复发的优点３ ，６ ，１２ 个月和３ ，５ 年治愈率分别为５１ ．２ ％ ，９０ ．２ ％ ，９５ ．１ ％ ，１００ ％ ，１００ ％ ；而无水乙醇组分别为７ ．５ ％ ，３７ ．５ ％ ，６５ ．０ ％ ，８７ ．５ ％ ，９０ ．０ ％ ，两组间比较均有显著性差异（ Ｐ＜ ０ ．０５ ，＜ ０ ．０１ ，＜ ０ ．０１ ，＜ ０ ．０５ ，＜ ０ ．０５） 。５ 年观察组合硬化剂组无复发，无水乙醇组１ 例好转，３ 例（７ ．５ ％ ） 复发（ Ｐ＜ ０ ．０５） 。结论：硬化药物组合序贯应用，先?更多还原

【Abstract】 Objective:To study the action of sclerosing complex agents on the gallbladder wall of hybrid rabbits.To observe the Long term clinical therapeutic on treating hepatic cysts with sclerosing complex agents.Method:The sclerosing complex agents consisting of tetracycline and dexamethasone,was injected into the gallbladder of rabbits to observe the action of comparing the sclerosing complex agents with normal saline and absolute ethylalcohol on the gallbladder wall.To observe the therapeutic effects of comparing the sclerosing comples agents with absolute ethylalcohol in treating renal cysts.Therapeutic group using the sclerosing comples agents were 41 cases (male 23,female 18,age from 43 to 72 years old).Control group using ethylalcohol were 40 cases(male 28,female 12,age from 45 to 70 years old).Results:Animal experiment had shown that the tissue cells of gallbladder in normal saline group had not any abnormal changes.But in absolute ethylalcohol group,a large amount of oozing liquid and blood appeared ,the absorption process was slow,and the fiber tissues had scarce proliferation.In sclerosing complex agents group,there was less oozing liquid,no blood in the gallbladder,and the absorption activity took place actively,the fiber tissues had grown up obviously.In clinical practice ,that the sclerosing complex agents possesses many advantages in the treatment of renal cysts,it can make the cysts to close quickly,reduce the exudation from early stimulating,and have no relapse.The third、sixth、twelfth months and third,fifth years after treatment ,the close rate of cysts were 51.2%,90.2%,95.1%,100% and 100%;but absolute ethylalcohol group were 7.5%,37.5%,65.0%,87.5% and 90.0% respectively.The differences between the two groups were significant (P<0.01,<0.01,<0.01,<0.05,<0.05).After fifth years,there were no relapsing cases in sclerosing complex agents group,but there were 1 improving case and 3 (7.5%) relapsing cases in absolute ethylalcohol group (P<0.05).Conclusion:The sclerosing agents should be used in sequence,i.e. first with high concentration of the drug to shrank adhesion and then with the remaining drug to stimulate epithelum to absorb the exudation.This combined method was proved to be an ideal and effective method for treating renal cysts clinically.更多还原