【摘要】 目的探讨各种类型病毒性肝炎患者血清一氧化氮（ＮＯ）变化及其临床意义。方法应用紫外分光光度计比色法测定血清ＮＯ含量。结果所有类型病毒性肝炎患者血清ＮＯ水平均较正常人高。急性肝炎患者血清ＮＯ水平与感染病原型无关，与血清ＡＬＴ及ＴＢｉｌ无明显相关。慢性肝炎，肝炎后肝硬化，重症肝炎中、晚期患者血清ＮＯ水平显著增高。且与血清ＡＬＴ、ＴＢｉｌ值呈正相关，与ＰＬＤ、ＬＨ、ＰＣⅢ水平呈正相关。与凝血酶原活动度（ＰＴＡ）及血清白蛋白（ＡＬＢ）呈负相关。结论急性肝炎时，ＮＯ轻度升高，是体对炎症的应答应反，此时发挥对肝细胞的保护作用。慢性肝炎、肝硬化及重症肝炎患者血清ＮＯ水平明显增高，表现对肝细胞的损伤作用，参与肝纤维化过程。ＮＯ是重症肝炎及肝硬化高动力循环的成因。更多还原

【Abstract】 ObjectiveTo study the serum nitric oxide (NO) level and its clinical significance in various viral hepatitis.MethodsThe serum NO level was detected by ultraviolet spetrophotometry.ResultsThe serum NO level in patients,with various viral hepatitis was higher than that in healthy ones.The serum NO level in patients with acute viral hepatitis has no relation to types of virus,and no relatioin to plasma ALT and TBil level.Serum NO level remarkably increased in patients with chronic hepatitis,liver cirrhosis and severe hepatitis in the late time.The serum NO level was positively related with plasma ALT,TBil,PLD,PCⅢ and LN.It was negatively related with plasma prothrombin activity (PTA) or plasma albumin level.ConclusionThe serum NO level was increased in patients with acute viral hepatitis,which may be due to reaction to the inflamation.At that time,serum NO level can reflect protective action to liver cells.The serum NO level was greatly increased in patients with chronic hepatitis liver cirrhosis and severe hepatitis.At this time,NO could damage liver cells and induce liver fibrosis.It was a result of hyperdynamic circulation in severe hepatitis and liver cirrhosis.更多还原