【摘要】 以饮用高氟水（１００ｐｐｍ）的方法制造了雄性大鼠慢性氟中毒模型。对中缝背核神经元Ｍｇ２＋－腺苷三磷酸酶（Ｍｇ２＋－ＡＴＰａｓｅ）和硫胺素焦磷酸酶（ＴＰＰａｓｅ）进行了定性、定量分析。结果表明：氟中毒大鼠中缝背核神经元内Ｍｇ２＋－ＡＴＰａｓｅ、ＴＰＰａｓｅ染色均浅于对照组，定量分析Ｍｇ２＋－ＡＴＰａｓｅ、ＴＰＰａｓｅ含量均减少。电镜观察氟中毒大鼠神经元内ＴＰＰａｓｅ颗粒减少，同时出现超微结构改变。这些结果提示：高氟可抑制某些酶的活性，并对中枢神经系统有直接损害更多还原

【Abstract】 The male rat model of chronic fluorosis was established with administration of large dose of fluoride in drinking water. The qualitative and quantitative analysis of Mg 2+ adenosine triphosphatase (Mg 2+ -ATPase) and Thiamin Pyrophosphatase (TPPase) of neurons in nucleus raphe dorsalis was done. The results showed that Mg 2+ -ATPase and TTPase activities in neurons were decreased and ultrastructures of neurons were also changed. These results suggest that fluoride may inhibit the activities of some enzymes and damage the central nervous system directly.更多还原