【摘要】 目的:为评价改水降氟对地方性氟中毒的防治效果。方法:检测分析了(未改水)病区组、改水病区组、非病区组8～12岁儿童的尿氟和氟毒性效应指标。结果:尿氟均值病区组明显高于改水病区组(P<0.01)和非病区组(P<0.01);尿羟脯氨酸(HOP)排泄量均值病区组亦明显高于改水病区组(P<0.01)和非病区组(P<0.01)改水病区组8～12岁儿童氟斑牙患病率由10年前的82.4％降至6.45％,明显低于病区组(P<0.01)。斑釉齿指数呈依次递减趋势,病区组、改水病区组、非病区组分别为0.73、0.03、0.026。血清肌酸磷酸激酶(CPK)活性均值病区组非常明显地高于改水病区组(P<0.01)和非病区组(P<0.01)。上述各指标改水病区组与非病区组比较,均无显著性差异(P>0.05)。结论:改水降氟后,人群氟暴露水平下降,致使体内氟负荷减轻,氟毒性效应指标改善,起到了明显的防护作用。更多还原

【Abstract】 To assess the effects of defluoride of drinking water. Methods:The urine fluorine and indices of fluoride toxic offecting were determined for three groups of children which were 8 - 12 year old. The three groups were nondefluoride group,defluoride group and non - epidemic area group. Results: The means of urine fluorine of non - defluoride group was much higher then that of defluoride (P < 0.01) and non - epidemic area group( P < 0.01) . The mean of urine hydroxyproline ( HOP) was much higher than that of defluoride group( P < 0.01) and non - epidemic area group ( P < 0.01). After ten years of defluoride of drinking water,the rate of dental fluorosis dropped from 82.4%to 6.45% .The rate 6.45% was much lower than that of non - defluoride group ( P < 0.01) . The dental fluorosis indices of non - defluoride group, defluoride group and non-epidemic area group were decrasing progressively,namely 0.73,0.03.,0.026. In the non-defluoride group the mean of activity of urine creatine phosphokinase(CPK) was much higher than that in defluoride group ( P < 0.01) and non - epidemic area group (P<0.01) .Between the defluoride group and non- epidemic area group,the indices mentioned above were no significantly defference ( P > 0.05) . Conclusion; After defluoride of drinking watwr, the body fluoride load come down and indices of fluoride toxic effecting be improved,because of the decresing of levels of exposure to fluorine.更多还原