【摘要】 目的应用动态血压监测及实验室检查评价乌拉地尔对高血压病的疗效以及安全性。方法25例高血压病患者停用降压药物，安慰剂治疗，1周后口服乌拉地尔60mg，Bid，疗程4周。应用乌拉地尔前后进行动态血压监测及血糖、血脂、尿酸、肝肾功能、胰岛素水平检测。结果用乌拉地尔4周后与用药前相比，患者收缩压、舒张压均明显下降（P＜0．01），血糖、血脂、肝肾功能、血尿酸及糖负荷后60分钟、120分钟血胰岛素水平未受影响，而空腹胰岛素水平降低（P＜0.01）。结论乌拉地尔是一种安全有效的抗高血压药物，对血糖、血脂、尿酸及肝肾功能无影响，能改善胰岛素抵抗。更多还原

【Abstract】 in order to evaluate the effect of ebrantil by ABPM technique and laboratoryexamination in 25 patients with hypertension before and after treatment with ebrantil. Bloodglucose, blood lipid, hepatic and renal function, uric acid and plasma insulin were measured. 4weeks after treatment, SBP and DBP dropped significantly (P <0.01),blood glucose of 0, 60 and120 minutes, blood insulin of 60 and 120 minutes after oral glucose load and blood lipid level,hepatic and renal function, uric acid were not significantly different before and after treatment (P<0. 05),while the fasting blood insulin level was lower than that in pre-treatment (P<0.01 ). Itis concluded that ebrantil is a safe, effective and tolerable antihypertion agent. Laboratoryexamination shows that ebrantil could improve insulin resistance and has no influence on hepaticand renal function,blood lipid,blood glucose and uric acid.更多还原