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桂枝汤有效部位A对体温的双向调节作用及其机理研究——对大鼠下丘脑PGE2含量的影响

Effect and Mechanism of Active Fraction A of Guizhi Decoctionon Dualdirectional Thermoregulation——Effect on Prostaglandin E2 in Hypothalamus of Rats

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【作者】 谭余庆李晓芹霍海如郭淑英周爱香田甲丽孙玉茹贺玉琢姜廷良

【Author】 Tan Yuqing, Li Xiaoqin, Huo Hairu, Guo Shuying, Zhou Aixiang, Tian Jiali, Sun Yuru, He Yuzhuo, Jiang Tingliang(Institute of Chinese Materia Medica, China Academy of TCM, Beijing, 100700)

【机构】 中国中医研究院中药研究所

【摘要】 在酵母诱导的发热大鼠中,桂枝汤有效部位A可使下丘脑前列腺素E2(PGE2)水平下降;在安痛定诱导的低体温大鼠,则使PGE2水平升高。

【Abstract】 The active fraction A (Fr. A) isolated from Guizhi decoction, which was orally administered, might cut down the rise of body temperature induced by yeast. The Fr.A also went up the hypothermy induced by aminopyrine intravenously. It lowered the content of PGE2 in febrile rats and raised the content in hypothemic rats in hypothalamus. The results indicate that Fr.A may regulate body temperature in dualdirection by means of promoting or inhibiting the metabolism of PGE2, a febrile medium in centre.

【基金】 国家自然科学基金
  • 【文献出处】 中国实验方剂学杂志 ,CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE , 编辑部邮箱 ,1998年02期
  • 【分类号】R285.5
  • 【被引频次】38
  • 【下载频次】180
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