【摘要】 研究了头孢唑啉钠与７，７，８，８－四氰基对二次甲基苯醌（ＴＣＮＱ）的荷移（ＣＴ）反应，确立了荷移反应的最佳条件。结果表明：在丙酮－甲醇介质中，两者于３０℃水浴中恒温３０ｍｉｎ即可形成１∶２的络合物，在其最大吸收波长７４３ｎｍ处表观摩尔吸光系数ε＝１７６×１０４Ｌ·ｍｏｌ－１·ｃｍ－１，在０～２４ｍｇ／Ｌ范围内符合比尔定律线性关系。方法的相对标准偏差小于３％（ｎ＝１０）。对形成ＣＴ络合物的机理进行了探讨。并应用拟定的方法对样品注射用头孢唑啉钠进行了含量测定，结果与标准方法一致，回收率符合要求更多还原

【Abstract】 The charge-transfer(CT) complex formed between cefazolin sodium as the donor and 7,7,8,8_tetracyanoquinodimethane(TCNQ) as the acceptor in acetone-methanol has been studied by spectrophotometric method.Beer’s law is obeyed in the range of 0～24 mg/L of cefazolin sodium.The apparent molar absorptivity of CT complex at 743 nm is 1 76×10 4 L%( n=10 ).The method has been applied to the determination of cefazolin sodium in injections with satisfactory results.更多还原