【摘要】 ①目的探讨脑梗塞病人血浆卵磷脂－胆固醇酰基转移酶（ＬＣＡＴ）活性与脂蛋白及红细胞膜脂质含量的关系，②方法应用外加底物法铡定４８例脑梗塞病人和３６例健康人血浆ＬＣＡＴ括性，并检测血浆高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）和亚组分（ＨＤＬ２－Ｃ，ＨＤＬ３－Ｃ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、载脂蛋白Ａ－１和Ｂ（ａｐｏＡ－１，ａｐｏＢ）、红细胞膜胆固醇（ＲＢＣＭ－ＣＨ）和红细胞膜磷腊（ＲＢＣＭ－ＰＬ）的含量变化。③结果脑梗塞病人血浆ＬＣＡＴ活性、ＨＤＬ－Ｃ，ＨＤＬ２－Ｃ及ａｐｏＡ－１含量明显降低，血浆ＬＤＬ－Ｃ，ａｐｏＢ，ＲＢＣＭ－ＣＨ及ＲＢＣＭ－ＣＨ／ＲＢＣＭ－ＰＬ比值显著增高，与对照组比较差异有显著性（ｔ＝２．１４－３．２５，Ｐ＜０．０５，０．０１），血浆ＬＣＡＴ活性与ＨＤＬ－Ｃ，ＨＤＬ２－Ｃ及ａｐｏＡ－１呈正相关（ｒ＝０．３８４，Ｐ＜０．０１；ｒ＝０．２９８，Ｐ＜０．０５；ｒ＝０．３１９，Ｐ＜０．０５），而与ＬＤＬ－Ｃ，ＲＢＣＭ－ＣＨ呈负相关（ｒ＝－０．２９０，－０．３２３；Ｐ＜０．０５）。④结论脑梗塞病人脂质代谢异常与血浆ＬＣＡＴ活性降低有关。更多还原

【Abstract】 Objective To investigate the relationships between plasma lecithin cholesterol acyltransferase ( LCAT) ac- tivity and lipoprotein and red blood cell membrane (RBCM) lipid compositions in patients with cerebral infarction (CI). Methods LCAT activity was determined by a method of exogenous substrate in 48 cases of CI and 36 normal controls, high density lipopro- tein cholesterol (HDL-C) and its subgroups (HDL2-C, HDL3-C), low density lipoprotein cholesterol (LDL-C), apolipopratien A-1 and B CapoA-1 , apoB). RBCM-cholesterol (RBCM-CH) and RBCM-phospholipd (RBCM-PL) were also measured. Results LCAT activity decreased significantly in CI group; Compositions of plasma HDL-C, HDL2-C and apoA-1 were also reduced signifi- cantly; Compositions of plasma LDL-C, apoB, RBCM-CH and the ratio of RBCM-CH/RBCM-PL increased significantly(t=2.24 -3. 25, P< 0. 05 - 0. 01). Moreover, LCAT activity correlated positively with HDL-C, HDL2-C , apoA-1(γ=0. 384,0. 298, 0. 319;P<0. 01,0. 05,0, 05). and negitively correlated with LDL-C, RBCM-CH(r= -0. 290, -0. 323; P< 0. 05). Conclu- sion Abnormal lipid metabollism in CI patients is correlated with decreased LCAT activity. [更多还原