【摘要】 邻啡罗啉Ｃｕ是一种具有核酸酶活性的配合物，可产生多种形式的ＤＮＡ损伤，包括碱基修饰、异常碱基位点、链断裂及交联等．近年来，邻啡罗啉Ｃｕ因其切割核酸的性质及作为一种可产生活性氧的模型，引起了学者们浓厚的兴趣，在自由基生物学与医学及核酸化学领域受到广泛的关注．更多还原

【Abstract】 Phenanthroline Cu is a complex that have nuclease activity, it can induce several kinds of DNA damage, including base modifications, abasic sites, strand breaks and DNA protein crosslinks. There is a considerable interest on this complex in recent years in the area of free radical biology and medicine as well as nucleic acids chemistry, for the role of phenanthroline Cu as a model of generating reactive oxygen species and as a chemical nuclease.更多还原