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基因重组乳链球菌防龋疫苗主动免疫防龋研究 Ⅲ.静脉内注射免疫孕兔的实验研究

A Study on Anticaries Activity of Genetic Recombinant Vaccine of Streptococcus lactis Ⅲ. Immunization in Vein with Recombinant S. lactis in Pregnant Rabbits

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【作者】 刘建国; 樊明文; 边专; 汪喻忠; 陈罕;

【Author】 Liu Jianguo, Fan Mingwen, Bian Zhuan, et al College of Stomatology, Hubei Medical University Ling Junqi College of Stomatology, Sun Yatsen University of Medical Sciences

【机构】 湖北医科大学口腔医学院;

【摘要】 利用ELISA法观察携带有变形链球菌表面蛋白基因的重组乳链球菌HL107经静脉内注射免疫孕兔后诱导机体免疫应答情况。结果表明,免疫1周后,血清和乳清中特异性IgG型抗体明显升高,并持续数周。提示重组乳链球菌HL107具有变形链球菌表面蛋白抗原PAc的免疫原性,能激发机体的系统免疫应答

【Abstract】 The effects of immunization in vein with recombinant S.lactis HL107 carring the S.mutans surface protein PAc gene in pregnant rabbits were studied.The results indicated that specific antiPAc IgG in serum and milk were obviously induced 1 week after immunization and retained at high level for several weeks. It suggests that the recombinant S.lactis HL107 possessing immunogencity of S. mutans surface protein PAc is able to stimulate specific systemic immune response against PAc.

【关键词】 变形链球菌; 乳链球菌; 表面蛋白抗原; 防龋疫苗;
【Key words】 \; Streptococcus; mutans\; lactis\; surface; protein; antigen\; immune\; vaccine;
【基金】 国家自然科学基金
  • 【文献出处】 华西口腔医学杂志 ,WEST CHINA JOURNAL FOF STOMATOLOGY , 编辑部邮箱 ,1998年02期
  • 【分类号】R780.1
  • 【下载频次】46
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