【摘要】 本实验采用麻醉大鼠缺血及缺血/再灌心律失常法、同位素⁴⁵Ca^2-1内流示踪法,观察了牛磺酸抗大鼠心肌缺血40min缺血10min/再灌30min心律失常,并研究了缺血、缺血/再灌心律失常与⁴⁵Ca^1-1内流的关系及牛磺酸对心肌缺血10min后缺氧30min、缺血10min后再给氧30min⁴⁵Ca²⁺内流的影响。结果表明,牛磺酸100mg·kg—1能明显降低缺血、缺血/再灌心律失常中室颤（VF）发生率。缺血10min后缺氧30min,心肌⁴⁵Ca^2-1内流不明显,牛磺酸对其没有显著影响,缺血10min/再给氧30min,心肌⁴⁵Ca^2-1内流明显增加,牛磺酸能明显阻断⁴⁵Ca^2-1内流。证实缺血性心律失常与细胞补钙内流关系不明显,牛磺酸抗缺血性心律失常不是通过阻断钙内流起作用的,而再灌心律失常的发生与钙内流增加有关,牛磺酸抗再灌心律失常是通过阻断钙内流实现的。更多还原

【Abstract】 The effects of tallribe on ischemic ischemic/reperfusion arrhythmias and chang of 45Ca2-1 influx were stdudied in anesthetized rats.Methods; The arrhythmias were produced by coronary occlusion for 40min, 10min followed by repexfusion 30min,The 45Ca2-1 influx volume was determised by following the track of radioaclive isofope. Results: The results showed that taure 100mg · kg hadhe effect of antiarrhythmia indued by ischemia,reperfusion and in ischemia group the 45Ca2-1influx was not increased, in reperfusion qroup the 45 Ca2-1 infux was inrreased significantly. Tauring could inhibit 45Ca2+influx.Cobclusions: These findings indicated that ischemis arrhythmia waw not related with extracellular 45Ca2-1 influx, but reper fusion arrhythmin was related with extracellular 45Ca2-1 influr. Themechanisms of taurine antiarrhythmin ineduced by reperusion was inhibiting the 45Ca2-1influx.更多还原