【摘要】 目的：探讨补肾健脾法对重症哮喘的作用及其作用机理。方法：对重症哮喘采用补肾健脾药结合激素气雾剂（治疗组）和激素气雾剂（对照组）治疗。结果：近期随访，两组疗效相似，远期随访，治疗组疗效及肺功能改善要优于对照组，β兴奋剂用量及副反应少于对照组。治疗后，治疗组的Ｔ淋巴细胞对过敏原反应、血清ＩｇＥ、嗜碱细胞释放能力及嗜酸细胞数均较对照组明显下降；治疗组的嗜中性细胞吞噬能力提高，嗜中性细胞数及肾上腺皮质功能无明显变化，而对照组的嗜中性细胞数升高，吞噬能力及肾上腺皮质功能降低。结论：在防治重症哮喘中，补肾健脾法不仅对皮质激素起协同作用，更主要的是发挥免疫－神经内分泌的调节作用。更多还原

【Abstract】 Objective:To explore on prevention and treatment of severe asthma with reinforcing the Kidney and invigoration the Spleen Principle (RKISP)and its mechanism. Methods: Patients were treated with steroid aerosol (as control group), and both steroid aerosol and RKISP(as test group) respectively. Results: The markedly effective rate of the test group was higher than that of the control group, the doses of β-analeptic and the side-effect rates of the test group were lower than that of the control group, the pulmonary function of the test group was more remarkably improved. After treatment, the T cell hyperplasia response to specific allergen, the basphilic cell releasing capacity, the serum IgE and eosinophil of the test group were all reduced more obviously than those of the control group.In the control group, the neutrophil increased and the neutrophil phagocytic capability as well as the function of adrenal cortex were declined. While in the test group, the neutrophil phagocytic capability was raised, the neutrophil and the function of adrenal cortex had no significant changes. Conclusions: RKISP cooperated with steroid in relieving attack of asthma, and it was more important for it to display an obvious modulation action on immune and neuroendocrine system.更多还原