【摘要】 作者采用放射免疫分析法，观察酪氨酸类似物酪氨酰肼对离体培养大鼠黄体细胞3β-羟-甾体脱氨酶（3β-HSD）活性的影响，同时还观察了酪氨酰肼在拮抗hCG诱导孕酮生成作用中对3β-HSD活性的影响。结果显示：（1）0．2mmol／L酪氨酰肼明显抑制大鼠黄体细胞3β-HSD活性。（2）底物浓度较低时，酪氨酰肼对3β-HSD活性具有显著增强作用，随着底物浓度的增加，它的作用渐弱且转为抑制。（3）酪氨酰肼可明显抑制hCG诱导的3β-HSD活性。更多还原

【Abstract】 In the recent investigation,the effect of tyrosine hydrazide on 3βHSD activity of the cul tured luteal cells of rats was studied by the method of RIA assay. The experiments showed: (1) 0. 2 mmol/L tyrosine hydrazide significantly inhibited 3β-HSD activity. (2) Tyrosine hydrazide had biphasic effect on 3β-HSD activity at different concentrations of pregnenolone. (3)Tyrosine hydrazide decreased 3β-HSD activity induced by hCG.更多还原