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透明质酸产生菌种的筛选

SCREENING OF HYALURONIC ACID PRODUCING STRAIN

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【作者】 杜平中; 顾鸽青; 杜巧泉; 顾春露; 邱林华;

【Author】 DU Ping Zhong *, GU Ge Qing, DU Qiao Quan, GU Chun Lu, QIU Lin Hua (Shanghai Institute of Pharmaceutical Industry,Shanghai 200040)

【机构】 上海医药工业研究院;

【摘要】 从实验室和临床菌种中分离到一株透明质酸产生菌,定名为马链球菌SIPI1.728。该菌的发酵液经分离纯化得白色纤维状固体产物,其理化性质、UV、IR和1HNMR图谱与透明质酸相符。

【Abstract】 A strain of hyaluronic acid producing hemolytic streptococcus was isolated from experimental and clinical isolates and designated as Streptococcus equi SIPI 1.728.The white fibrous solid of product was obtained from the fermentation broth by means of ethanol precipitation,cetylpyridinium chloride precipitation and DEAE Sephadex A 50 chromatography.The physicochemical properties, UV,IR and 1HNMR spectra of this product were consistent with those of hyaluronic acid.

【关键词】 透明质酸; 马链球菌; 筛选;
【Key words】 hyaluronic acid; Streptococcus equi; screening;
  • 【文献出处】 中国医药工业杂志 ,CHINESE JOURNAL OF PHARMACEUTICALS , 编辑部邮箱 ,1997年05期
  • 【分类号】R446.6
  • 【被引频次】2
  • 【下载频次】177
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