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Several new targets of antitumor agents

Several new targets of antitumor agents

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【作者】 王兴旺胥彬

【Author】 WANG XingWang, XU Bin1(Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China) 1 Correspondence to Prof XU Bin. Phn: 862164311833. Fax: 86216437 0269.Received 19970117 Accepted

【机构】 中国科学院上海药物研究所

【摘要】 甲胎蛋白作为肝癌生长的促进因子,是抗肝癌药的新靶点.用药物抑制或封闭癌基因表达为治疗肿瘤开辟了新途径.诱导肿瘤细胞向正常细胞分化已成为肿瘤药物治疗的又一崭新策略.诱导肿瘤细胞凋亡是许多抗肿瘤药的共同作用方式;用自杀基因靶向治疗肿瘤优化了目前的化学治疗,具有广阔的应用前景.

【Abstract】 Alphafetoprotein (AFP), as a hepatomapromoting factor, has become a new target of antihepatoma agents. It is a new approach for the treatment of tumors to inhibit or block oncogene expression. Informational drugs are being developed for gene therapy applications as inhibitors of oncogene expression. The induction of tumor cell differentiation is another new strategy of drug therapy of tumors. Common action mode of many antitumor drugs is to induce apoptosis of tumor cells. Suicide genes, as targeting therapy of tumors, improve the present chemotherapy, exhibiting broad application prospects.

  • 【文献出处】 Acta Pharmacologica Sinica ,中国药理学报(英文版) , 编辑部邮箱 ,1997年04期
  • 【分类号】R979.1
  • 【被引频次】5
  • 【下载频次】6
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