【摘要】 尼莫地平是一种钙离子拮抗剂，现巳用于急性脑缺血的治疗。本文通过观察大鼠急性脑缺血模型及假手术组循环中及脑组织内一氧化氮（NO）、内皮素（ET1）水平，并观察尼莫地平对大鼠脑缺血模型循环中及脑组织的NO、ET1水平的影响，发现模型组循环中的NO水平较假手术组有下降趋势，但无明显统计学差异（P＞0．05），ET1的水平较假手术组显著升高（P＞0．05）;脑组织中NO、ET1含量均较假手术组显著升高（P＜0．05）。尼莫地平具有显著升高急性脑缺血大鼠循环中NO，显著降低循环中ET1，显著降低脑组织中NO、ET1的水平，说明尼莫地平具有促进脑缺血时大鼠的脑部供血，保护由于脑缺血引起的脑组织损害。更多还原

【Abstract】 Nimodipine as a calcium channel antigonist, bas been used in the treatment of acute brain iechemia. The article was oberved the contents of Nitric Oxide (NO) and Endotbelinl (ET1 ) in the circulation and brain tissue in models of acute brain ischemic and sham-operated rats, and the levels of No and ET1 in the circulation arid brain tissue in acute brain ischemic models with nimodipine. It was found that in compared with Sham -operated group, the levels of No in circulation of the model group had a tendency to decrease, but had no statistical difference (P>0. 05). the levels of ET1 was significantly increase (p<0. 05) ; in brain tissue, the levels of NO and ET1 were all inereased. Nimodipine has definite effects on the increasing the levels of NO in circulatin of the models. decreasing the levels of ET1, inhibiting the increase of NO and ET1 in brain tissue, It was suggested that nimodipine may improve thebrain blood flow, prevent the bain damage resulting from the acute brain ischemia.更多还原