【摘要】 应用逆转录─多聚酶键反应（RT－PCR）检测卵巢癌12例，大肠癌15例，肝癌2例肿瘤多药耐药基因（MDR1）表达。以长春新碱（VCR）敏感细胞株KB和耐药株KBr分别作阴性及阳性对照，卵巢癌患者MDR1表达增高者为50％（6／12），大肠癌增高者75％（10／15）卵巢癌MDR1表达低者化疗效果较好；大肠癌患者MDR1表达高者似与术前局部用化疗药有关。更多还原

【Abstract】 Used VCR-sensitive KB cell line and VCR-resistant KBr cell line as negative and positive control respectively,the authors deterned Multiple Drug Resistant qene 1 (MDR1) mRNA in patients with ovarian cancer or colorectal cancer with RT-PCR. High level expression of MDR1 was found in 6/12 of ovarian cancer and 10/15 of colorectal cancer. The deternination of MDR1 may be helpfulin designing chemotherapeutic protocols in the patients with luqh level expression of MDR1更多还原