【摘要】 在碳酸氢钠存在下，用一步法以苯并咪唑、甲醛、盐酸羟胺为原料，合成了N，N-双-（苯并咪唑基甲基）羟胺（Ⅰ）；苯并咪唑、甲醛与甲胺在甲苯溶液中回流分水，得到N，N-双-（苯并咪唑基甲基）甲胺（Ⅱ）．用N，N-双-（苯并咪唑基甲基）羟胺与格氏试剂反应合成了4个N，N-双取代羟胺（Ⅲ）．用N，N-双-（苯并咪唑基甲基）羟胺与丙烯酸甲酯、丙烯酸乙酯或反-丁烯二酸二乙酯发生1，3-偶极环加成反应，得到2－（苯并咪唑基甲基）异唑啉-5-羧酸酯或2-（苯并咪唑基甲基）异唑啉-4，5-二羧酸酯．用IR，1HNMR和元素分析确定了它们的结构．更多还原

【Abstract】 In the presence of sodium bicarbonate, the one step reaction of benzimidazole,formaldehyde and hydroxylamine hydrochloride was studied. New N, N- bis- forbenzimidazolylmethyl) hydroxylamine (Ⅰ) was obtained in high yield. The Mannich reaction ofbenzimidazole, formaldehyde and methylamine, under the condition of refluxing in toluene solution and remove water, form the new compound N,N- bis - (benzimidazolylmethyl) methylamine (Ⅱ). (Ⅰ) react with the Grignard reagents of alkyl brocade to obtain four N,N -disubstitutedhydroxylamines. The 1,3 - dipolar addition reaction of (Ⅰ) with arylic esters or fumaric ester werealso studied to obtain three new 2 - benzimidazolylmethylisoxazoline - 5 - carboxylate esters or4,5- dicarboxylate diester. Their structures are deduced by IR, 1HNMR and elemental analysis.更多还原