【摘要】 用四血管夹闭模型法建立家兔脑缺血再灌注损伤模型，在缺血前静脉注射补阳还五汤（３．９ｇ／ｋｇ）可抑制脑缺血再灌注损伤后脑组织血栓素Ｂ２（ＴＸＢ２）的升高、脑组织６－酮－ＰＧＦ１α的降低，降低再灌注后脑组织的钙含量，但对脑组织ｃＡＭＰ含量的增加无明显影响，提示补阳还五汤抗脑缺血再灌注损伤的作用机理与调节脑内ＴＸＡ２／ＰＧＩ２平衡、抑制脑细胞Ｃａ２＋超负荷等有关更多还原

【Abstract】 The rabbit cerebral ischemic postischemic reperfusion injury model was founded by using the tetra vessels obstruct.The results showed that Bu Yang Huan Wu Tong (BYHWT),which was injected in veins before obstruct,could inhibit the increase of thromboxan B 2 (TXB 2) (P<0 05) and the decrease of 6 keto PGF 1α (P<0 05) in brain tissue and declined the calcium contents but didnt have effect on cAMP contents in brain tissue.All above suggested that the mechanisms of BYHWT against the cerebral ischemic postischemic reperfusion injury might have bearing on adjusting the balance of TXA 2/PGI 2 and inhibiting the Ca 2+ hypercharge in the cerebral cells.更多还原