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格林-巴利综合征患者血清髓鞘脂抗体检测及其临床意义

Serum Levels of Anti-myelin Sheath Antibody and Their Clinical Significance in Patients with Guillain-Barre Syndrome

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【作者】 沈雪莉李绍英戚其学李玉芬

【Author】 Shen Xueli; Li Shaoying; Qi Qixue; Li Yufen (Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang 110001)

【机构】 中国医科大学第一临床学院神经内科

【摘要】 应用ELISA方法对28例格林-巴利综合征(GBS)患者和30例正常对照者、30例疾病对照者进行血清抗髓鞘脂抗体检测,并对其中5例进行动态观察。结果发现:GBS患者血清抗髓鞘脂抗体水平增高,与正常和疾病对照组相比有非常显著性差异(P<0.01)。GBS患者髓鞘脂抗体出现的阳性率为21.4%,GBS患者髓鞘脂抗体水平下降与临床症状的改善相一致。

【Abstract】 We used ELISA to determine the serum anti-myelin sheath antibody in 28 patients with Guillain-Barre syndrome 30 healthy subjects and 30 patients with other neurologic diseases.A dynamic observation was performed in 5 patients with GBS. The result showed that the serum anti-myelin sheath antibody increased in patients with GBS, compared with the other two groups,and the difference was significant.The positive rate of serum antimyelin sheath antibody titers in GBS patients was correlated with clinical symptomatic improvement.

  • 【文献出处】 中国神经免疫学和神经病学杂志 ,CHINESE JOURNAL OF NEUROIMMUNLOLGY AND NEUROLOGY , 编辑部邮箱 ,1996年04期
  • 【分类号】R745.44
  • 【下载频次】24
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