【摘要】 目的探索近视眼的发病机理。方法采用形觉剥夺方法,在海赛克鸡雏眼建立了近视眼动物模型。出生后第5天,实验组的15只鸡雏缝合单侧眼睑以获得完全性形觉剥夺。15只鸡雏用于对照。形觉剥夺后第15、30和45天,每组各取5只眼验光,游标卡尺测量眼球前后轴长、水平及垂直径,同时进行病理学观察。结果形觉剥夺导致了近视性屈光状态异常(P<0.001)。眼球的前后轴长延长(P<0.005)、水平径和垂直径延长(P<0.05)。并观察到明显的病理学改变:巩膜软骨细胞层增厚,软骨细胞和双核细胞数量增加。巩膜纤维层变薄。结论研究结果提示,形觉剥夺是产生近视眼的主要原因。更多还原

【Abstract】 Objective The study was designed to approach the pathogenesis of myopia.Method Haisaik chickens were used to establish the animal models of myopia and form deprivation method was applied.Monocular eyelids were sutured for form deprivation on the 5th day after chicken birth.Results Form deprivation leads to myopic refractive abnormality (P<0.001).The ocular anteroposterior axis (P<0.005),transverse and vertical diameters lengthen (P<0.05).In the mean time,obvious patho- logic changes were found.The cartilaginous cell layer of the sclera became thicker,the numbers of chondrocytes and binucleate cells were greater,and the fibrous layer of the sclera was thinner.Conclu- sion Form deprivation is the main cause of the development of myopia.更多还原