【摘要】 目的研究蚕蚀性角膜溃疡邻近球结膜的免疫病理学变化及病变组织中免疫调节状态、组织细胞和白细胞的粘附作用与其发病的关系。方法应用免疫组织化学染色方法对14例(15只眼)蚕蚀性角膜溃疡病变邻近的球结膜组织中 T 淋巴细胞亚群(T_总、T_H、T_S)、B 淋巴细胞、细胞间粘附分子-1(intercellular adhesion molecule-1,ICAM-1)及淋巴细胞功能相关抗原-1(lymphocyte function-associate antigen-1,LFA-1)的分布进行检查。结果发现病变组织中辅助 T 细胞/抑制 T 细胞(T_H/T_S)比值异常升高,结膜组织细胞异常表达 ICAM-1,浸润的炎性细胞普遍表达 LFA-1。结论周边部角膜及邻近球结膜组织中免疫功能亢进可能是导致本病的直接原因。同时,ICAM-1和 LFA-1的相互作用也是参与发病的重要因素。更多还原

【Abstract】 Objective The study was designed to investigate the immunopathology of bulbar con- junctive adjacent to Mooren’s ulcer of the cornea and to evaluate the roles of immune regulation status, the adhesive action of conjunctival cells and leucocytes in the pathological tissue in the pathogenesis of the lesion.Method 15 limbal conjunctival specimens from 14 patients with the progressive Mooren’s ulcer were examined by using immunohistochemical stainings for T-lymphocyte and its subsets (Pan-T, T_H and T_S),B-lymphocyte,intercellular adhesion molecule-1 (ICAM-1) and lymphocyte functionasso- ciated antigen-1 (LFA-1).Result The ratio of T-helper to T-suppressor cells (T_H/T_S) in Mooren’s ulcer group was significantly higher than that in the normal group,ICAM-1 was strongly expressed on conjunctival cells,whereas LFA-1 was strongly expressed in infiltrating leukocytes.Conclusion The immune hyperfunction at the peripheral corneal lesion and its adjacent bulbar conjunctiva possibly is the direct cause of the pathogenesis of Mooren’s ulcer.Simultaneously,the mutual action of ICAM-1 and LFA-1 might play an important role in the development of the disease.更多还原