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吡喹酮涂肤纸巾的研制

The Preparation of the Praziquantel Wet Towel

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【作者】 宋俊生梁建宗徐宁宁周立新

【Author】 Song Junsheng;Liang Jianzong;Xu Ningning; Zhou Lixin(Nanjing Institute of Materia Medica Nanjing 210009)

【机构】 南京药物研究所

【摘要】 经处方筛选和包装材料选择试验,以乙醇为溶剂,二甲基亚砜为促渗透剂,制备了吡喹酮涂剂,其防护血吸虫尾蚴侵袭作用在水中可维持4h以上,继以特定纸巾吸储药液,用铝箔复合膜包装袋制成了防疫现场实用的新型血防用药品。初步稳定性试验结果良好。

【Abstract】 The Praziquantel wet towel was prepared and used as a care agent in protecting skin from snail fever(Schistosomiasis).It was composed of a special paper lowel,an alcohol solution containing praziquantel and a plastic film pouch.The main components of the solution were praziquantel,DMSO,and ethyl aicohol.Dimethyl sulfoxide was ued to enhance the permeation of praziquantel and made it possible that praziquantel stayed in skin cuticle and was effective against schislosomiasis for 4-8 hrs in epidemic water.The wet towel was stable under condition of 40℃ or 60℃ and might become a commerical product.

【关键词】 吡喹酮湿纸巾血吸虫病
【Key words】 PraziquantelPraziquantel wet towelSnail fever
  • 【文献出处】 中国药科大学学报 ,JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY , 编辑部邮箱 ,1996年11期
  • 【分类号】R944.9
  • 【被引频次】5
  • 【下载频次】73
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