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新疆蒙古族、锡伯族新生儿HbF中~Gγ/~Aγ、~Aγ~I/~Aγ~T比值测定及基因图谱分析

~Gγ /~ Aγ/~ Aγ~I /~Aγ~T Ratios of Fetal Hemoglobin of Mongol and Sibo Ethnic Newborns in Xinjiang and Gene Mapping of Seven Cases with Abnormal Ralio

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【作者】 钱渡光炜庄怡马梅荪陈松森陈卫东梁值权周静

【Author】 Qian Du; Guang Wei; Zhuang Yi; Ma Meisun(Department of Biology, Xinjing Medical College, Urumuqi 830054)Chen Songsen; Chen Weidong; Liang Zhiquan (Basic Medical Research Institute, Chinese Academy of Medical Sciences, Beijing 100005)Zhou Jing(Health Schoo

【机构】 新疆医学院生物学教研室!乌鲁木齐830054中国医学科学院基础医学研究所!北京100005中国医学科学院基础医学?

【摘要】 用HPLC法测定新疆蒙古族78例、锡伯族60例新生儿胎儿血红蛋白(HbF)中Gγ/Aγ以及AγI/AγI比值。%Gγ均值为:蒙古族73.99%,锡伯族74.59%。%GγI均值分别为蒙古族56.04%和锡伯族64.33%。在蒙古族中发现AγT纯合体4例、杂合作12例;锡伯族中发现AγT杂合体6例。蒙古族中AγT基因频率(ρAγT)为0.128,锡伯族为0.05

【Abstract】 Gγ / Aγ, AγI/AγT Ratios of fetal hemoglobin (HbF) in 138 cases of newborns of Mognol(n= 78) and Sibo (n = 60) ethnic groups in Urumuqi, Xinjiang were determined by HPLC. The means of%Gγ of Mongol and Sibo ethnic groups were 73.99% and 74.59% respcctively. 12 AγT cases ofheterozygotes in Mongol, 6 in Sibo and 4 cases of AγI homozygotes in Mongol were found. The frcquen-cies of AγT gcne were 0.128 in Mongol and 0.05 in Sibo respectively. The means of AγT of Mongol andSibo ethnic groups were 56.04% and 64.33% respectively.

【基金】 国家自然科学基金
  • 【文献出处】 遗传 ,Hereditas(Beijing) , 编辑部邮箱 ,1996年02期
  • 【分类号】Q987
  • 【下载频次】27
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