【摘要】 目的：观察预处理（ＰＣ）对乳兔心肌细胞缺氧复氧（Ａ－Ｒ）损伤的影响。方法：采用心肌细胞Ａ－Ｒ模型，用短暂缺氧进行预处理。结果：缺氧预处理能提高Ａ－Ｒ后心肌细胞存活率（７７．２１±３．１０ＶＳＡ－Ｒ组５９．８３±２．１０．Ｐ＜０．０１）．减少ＭＤＡ产生（０．７５±０．０２ＶＳＡ－Ｒ组１．６１±０．０８ｎｍｏｌ／ｍｇｐｒ，Ｐ＜０．０１）及乳酸脱氢酶的漏出（Ｐ＜０．０１）。结论：离体乳兔心肌细胞存在ＰＣ保护现象。更多还原

【Abstract】 Abstract: Objective: To investigate the effect of hypoxic precoOnditioning (HPC) on anoaia - reoxygenation (A - R) injury of neonatal rabbit cardimyocyte.Methods: On the model of cardiomyocyte A - R. HPC was performed by transient hypoxia. Results:HPC improved viability of cardiomyocytes during A-R (77. 2 ±3.1 vs A - R group 59. 8 ± 2.6%, P<＜0.01), reduced formation of MDA (0.75 ± 0.02 vs A-R group 1.61 ±0.08 nmol/mg pr., p＜0.01)and leakage of LDH (P＜ 0. 01 ) in myocytes. Conclusion: There exists protecive phenomenon of preconditioning in cardiomyocyte of neonatal rabbit in vitro.更多还原