【摘要】 应用ＬＳＡＢ免疫组织化学方法研究６７例胃标本中ｐ５３和ｃ－ｍｙｃ的表达与多药耐药性（ＭＤＲ）的关系。结果显示本组胃癌中ｐ５３阳性３２例，阳性率４７．８％；ｃ－ｍｙｃ阳性３７例，阳性率５５．２％；Ｐ－ｇｐ阳性３９例，阳性率５８．２％。ｐ５３的异常表达与ＭＤＲ－１基因表达呈显著正相关（ｒ＝０．３７，ｐ＜０．０５），而ｃ－ｍｙｃ和ｍｄｒ－１的表达无明显相关。提示ｐ５３异常表达可增加ｍｄｒ一１基因的表达，从而使胃癌细胞获得ＭＤＲ表型。更多还原

【Abstract】 By LSAB immunohistochemical technique,the correlation between expressionof p53 and c-myc protein and multi-drug resistance(MDR)in 67 gastric carcinoma cases was stud-ied.Results:32 cases(47.8%)were p53 positive;37 cases( 55.2%)were c-myc positive and 39(58.2%)were P-gp positive.A significant correlation was found between p53 overexpression andmdr-1 gene expression(r=0.37, P< 0.05).Meanwhile,there was no significant correlation be-tween expression of c-myc and mrd-1.It is suggested that p53 overexpression may increase mdr-1gene expreassion so as to produce MDR of gastric carcinoma cells.更多还原