【摘要】 用低钙偏食饲料饲养大鼠,经饮水投氟复制骨软化型氟骨症动物模型,同时经饲料分别补充8g/kgCaCO₃、lg/kg Vc、0.05g/kg鱼肝油及40g/kg酪蛋白,然后用国产NM300型骨矿物质测量仪测定大鼠右侧胫骨及腰椎5（L₅）骨密度。实验结果表明,骨软化型氟骨症大鼠。骨钙减少、骨氟增加,骨密度在胫骨及L₅变化不尽相同,胫骨骨密度降低而L₅却未见明显改变。补钙后,增加了骨钙,降低了骨氟,提高了胫骨及L₅的骨密度。而补Vc鱼肝油及酪蛋白对各项指标均无改善作用。更多还原

【Abstract】 An experimental model of osteomalacia skeletal fluorosis was produced in rats kept on a monotonous diet of low calcium and drinking water supplemented excess fluoride (100g/L F-). Meantime the nutrition factors were added separated to the diets, including calcium carbonate 8g/kg diet, Vitamin C 1g/kg, Cod-fish-liver 0. 05g/kg diet and Casenin 40g/kg diet. Then the bone mineral density (BMD) of the right tibiae and the fifth lumbar (L5) of therats were determined through a 241 Am Single photon absorptiometry, and the bone calcium (Ca)and the bone fluoride (F) were studied. The results showed; (1) The significant decrease of bone Ca and in-crease of bone F in osteomalacia skeletal fluorosis, the significant decrease of BMD in right tibiae and no change in L5.(2) The calcium had the best improvement effect. When the calcium carbonate were added,bone Ca were increased and bone F decreased statistically,and the BMD both tibiae and L5 increased statistically to model group. There were no effects when Vitamin C, Codfish-liver and casenin were added.更多还原